普通基托与含纳米二氧化钛基托功能矫治器对儿童龋病活性影响的比较

Ordinary and nano-titanium dioxide denture appliances influence caries activity in children: A comparative study

目的：为克服功能矫治器治疗过程中龋病发生率增高的缺陷,应用含纳米二氧化钛基托功能矫治器矫治,观察其对龋病活跃性的影响,并与普通基托相比较。方法：实验于2005-11/2007-05在中国医科大学口腔医学院中心实验室完成。选择随沈阳市口腔医院正畸科接受普通基托功能矫治器矫治半年的儿童35例和未接受正畸治疗的儿童35例,年龄8~11岁,均为替牙列。两组均进行一次DentocultSM龋病活跃性的检测,然后普通基托正畸组进入保持期后更换含纳米二氧化钛基托的功能矫治器半年后再进行一次DentocultSM龋病活跃性的检测。实验经医院伦理委员会审批,患者家长对实验知情同意。结果：戴用普通基托功能矫治器正畸儿童的DentocultSM值明显高于非正畸儿童（P〈0.01）,戴用含纳米二氧化钛基托功能矫治器DentocultSM值与非正畸儿童比较差异无显著性意义（P〉0.05）。结论：戴用普通基托功能矫治器的正畸儿童龋病活跃性增高,对龋病的易感性增加。戴用含纳米二氧化钛基托功能矫治器的正畸儿童龋病活跃性恢复,龋病的易感性呈下降趋势。提示纳米二氧化钛材料具有抗菌性。

AIM： The denture appliances impregnated with nano-titanium dioxide are used to reduce the incidence of caries during denture appliance treatment. This article investigates the influence of different denture appliances on caries activity in children, and compares with the ordinary denture appliances. METHODS： Experiments were performed at the Central Laboratory, Stomatologieal Medical College, China Medical University from November 2005 to May 2007. Thirty-five children treated with ordinary denture appliances for half a year and thirty-five untreated children were enrolled at Deparanent of Orthodontics, Shenyang Stomatological Hospital. They were 8-11 years and in transitional dentition. Dentocult SM caries activity was determined once in the two groups. The children in the ordinary denture appliances group were treated with denture appliances impregnated with nano-titanium dioxide when the treatment was in retention phase. Half a year later, Dentocult SM caries activity was determined again. The experimental procedures were approved by the Hospital Ethical Committee. Family members of each patient signed a informed consent. RESULTS： The Dentocult SM values in children treated with ordinary denture appliances were significantly higher than those in untreated ones （P 〈 0.01）. There was no significant difference in the Dentocult SM values between children treated with denture appliances impregnated with nano-titanium dioxide and untreated children （P 〉 0.05）. CONCLUSION： The caries activity increases in children treated with fixed orthodontic appliances. The caries activity of treated children who take functional appliances impregnated with nano-titanium dioxide decreased. It is indicated that the materials coated with nano-titanium dioxide have antibacterial activities.