体外膜肺氧合治疗ARDS的实验研究

Experimental Research on Extracorporeal Membrane Oxygenation in Treatment of Acute Respiratory Distress Syn-drome

目的:探讨体外膜肺氧合(ECMO)治疗ARDS的有效性和可行性。方法:采用油酸注入法制备犬ARDS模型,将15只犬随机分为3组:对照组(n=5)、模型组(n=5)及V-VECMO治疗组,通过监测血气指标、血流动力学指标、血管外肺水含量及肺顺应性指标,评价V-VECMO疗效。结果:V-VECMO明显提高了动脉和混合静脉血氧分压,增加氧供,增加心排血量,降低肺血管阻力,减轻肺水肿,肺功能明显改善。结论:ECMO治疗ARDS有效和可行,为临床治疗ARDS提供了新思路。

Objective：To investigate the efficacy of extracorporeal membrane oxygenation （ECMO） in treatment of acute respiratory distress syndrome（ARDS）. Methods：Fifteen dogs were randomly divided into three groups：control group （n = 5）, ARDS model group （71 = 5） and V-VECMO group （n = 5） . Effect of V-VECMO was evaluated by monitoring blood gas, hemodynamics index and lung compliance. Results： V-VECMO significantly increased PVO2, PaO2 and cardiac output, decreased pulmonary vascular resistance, reduced pulmonary edema and improved lung function. Conclusions： ECMO is effective in treatment of ARDS.