2型糖尿病患者血尿酸水平与心脑血管病关系探讨

The study on the dependablity of blood uric acid and cardia-cerebrovascular disease in 2-type diabetic

目的探讨血尿酸水平对2型糖尿病患者心脑血管并发症的影响。方法对我院2005年3月至2007年9月2型糖尿病住院患者临床资料进行回顾性分析。结果A组（低血尿酸）血胆固醇（TC）、三酰甘油（TG）、低密度脂蛋白胆固醇（LDL-C）均明显低于B组（高血尿酸）（P〈0．05），高密度脂蛋白胆固醇（HDL-C）明显高于B组，A组血浆比黏度和纤维蛋白原较B组明显降低（P〈0．05）；高血压、冠心病和脑卒中发生率均明显低于B组（P〈0．05）。纤维蛋白原、血浆比黏度、TC、TG、LDL-C、高血压、冠心病和脑卒中与2型糖尿病患者血尿酸水平明显，呈正相关（P〈0．05或〈0．01），HDL-C水平和2型糖尿病患者血尿酸水平呈负相关（P〈0．01）。结论血尿酸水平是影响2型糖尿病患者心脑血管并发症的独立危险因素。

Objective To investigate dependablity of blood uric acid and cardia-cerebrovascular disease in 2-type diabetic. Methods The clinical and laboratory datas were analyzed in 2-type diabetic,from Mar 2005 to Sep 2007,were treated in our hospital. Results Compared with Group B,TC,TG, LDL-C,blood plasma specific viscosity, profibrin and the incidence of hypertension, coronary artery disease and cerebral apoplexy were decreased in Group A （P〈0.05）; HDL-C increased in Group A （P〈0.05）;TC, TG, LDL-C, blood plasma specific viscosity,profibrin and the incidence of hypertension,coronary artery disease and cerebral apoplexy significantly direct correlated with the level of blood uric acid（P 〈0.05 and P〈0.01） and HDL-C significantly inverse correlated with the level of blood uric acid （P〈0.01）. Conclusion Blood uric acid may be the important factors on the cardia-cerebrovascular complication in 2-type diabetic.