对鼻腔淋巴瘤形态学及免疫组化表型的研究

Study on Morphology and Immunophenotype of Lymphoma in Nasal Cavity

目的鼻腔是结外常发生淋巴瘤的部位之一。为探讨鼻腔淋巴瘤的形态学改变及临床特点及临床预后。方法应用免疫组化方法及临床随访对42例鼻腔恶性淋巴瘤进行了组织学类型及临床治疗方法和预后的研究。结果发现鼻腔恶性淋巴瘤以NK/T细胞淋巴瘤为主(21例),其次是T细胞淋巴瘤(非特异型)(9例),以及其他类型,弥漫性大B细胞淋巴瘤(3例),粘膜相关淋巴瘤(3例),浆细胞肉瘤(1例),粒细胞肉瘤(2例)。结论鼻腔可发生的淋巴瘤种类较多,其生物学行为存在较大差异,各类淋巴瘤其免疫表型各有其特点,是病理诊断的重要依据和鉴别诊断要点,同时是临床治疗的前提。

Objective Nasal cavity and sinuses is a usual site of extranodal lymphoma. To investigate the types of lymphoma and clinical characteristics and treatment outcome. Methods Total 42 cases of lymphomas were reviewed rertospectively. The pathological types and clinical characteristics and prognosis were studied by immunohistochemistry and follow - up. Results Total 21 cases are NK/T cell lymphoma,9 cases are T cell lymphoma（ non -specific） ,3 diffuse large B cell lymphoma,3 MALT lymphoma, l plasma cell lymphoma and 2 myeloid sarcoma. Conclusion There are kinds of lymphomas in nasal cavity and sinuses which with definite pathological features and immunohistochemical phenotypes.