早、晚服用施慧达对原发性高血压疗效比较

Effects of taking levamlodipine in the morning and night on primary hypertension

目的评价早、晚服用施慧达对原发性高血压的降压疗效及毒副反应。方法将原发性高血压患者68例随机分为两组(分别命名为晨组与晚组),按2.5～5.0mg/d剂量分别于早餐或晚餐0.5h后口服施慧达4周,观察治疗前后降压疗效。结果与治疗前相比,两组对原发性高血压均具有显著降压效果,总有效率分别为85%、86%,但组间比较无统计学差异,两组中均未见有不良事件的发生。结论早、晚服用施慧达对原发性高血压均具有良好的降压效果,且均不易发生不良事件。

Objective To investigate the effects of Shihuida （levamlodipine） taken in the morning or night on primary hypertension. Methods 68 primary hypertension patients were divided into 2 groups randomly （named as morning group and night group respectively）. Shihuida was taken orally at a dose of 2. 5-5.0 mg/d 0. 5 h later after breakfast or dinner everyday during four weeks and its depressurization effect was examined after treatment. Results The results showed that taking Shihuida either at morning or evening could significantly lower patients＇ blood pressure,which the total effective rates was 85% ,86% respectively,no significant differences were observed between the 2 groups,however. It was also showed that no side-effect occurred during our treatment period. Conclusion Taking Shishuida both in the morning or evening cart significantly decrease blood pressure of primary hypertension patients without side-effect.