CD44v6和p16在宫颈上皮内瘤变及宫颈癌中的表达及意义

Expression of CD44v6 and p16 Protein in Cervical Intraepithelial Neoplasia and Cervical Carcinoma

目的探讨CD44v6和p16表达产物在宫颈上皮瘤样病变及宫颈癌中表达的意义。方法对正常宫颈鳞状上皮、宫颈上皮内瘤变(CIN)和宫颈癌组织共95例,采用免疫组织化学SP法,对宫颈癌变过程中CD44v6和p16蛋白进行研究,将结果进行统计分析。结果CD44v6蛋白在CIN中的表述高于正常宫颈上皮(P<0.01),在宫颈癌中的表达也高于正常宫颈上皮(P<0.01),且高于CIN中的表达(P<0.01),p16蛋白在CIN中的表达高于正常宫颈上皮(P<0.01),在宫颈癌中的表达也高于正常宫颈上皮(P<0.01);CD44v6和p16两种蛋白在CIN和宫颈癌中的表达无明显差异。结论CD44v6和p16蛋白的表达与宫颈癌的发生有关,提示这两种蛋白有可能作为高危人群早期筛查的一种免疫组化指标。

Objective To investigate the significance of expression of CD44v6 and p16 in cervical lntraepithelial neoplasia（CIN） and cervical carcinoma. Methods The expression of CD44v6 and p16 proteins of 95 cases of normal cervical tissue, cervical intraepithelial neoplasia and cervical carcinoma was detected by SP immunohistochemical staling and the results were correlate with the results. Results The expression of CD44v6 was significantly higher in CIN than innormal cervixes（P〈0.01）.It was significantly higher in cervical carcinomas than in normal cervixes（P〈0.01）, and higher than in CIN（P〈0.01）. The expression of p16 was significantly higher in CIN than in normal cervixes（P〈0.01）,It was significantly higher in cervical carcinomas than in normal cervixes（P〈0. 01）. No statistical difference of expression in cervical carcinomas and CIN was found between CD44v6 and p16 protein. Conclusion The results indicated that the expression of CD44v6 and p16 protein was associated with the Carcinogenesis of eervical cancer. It is suggested that CD44v6 and p16 expression may be taken as aneffecfive immunohistochemical makers for early detection.