摘要
Absorption distribution and excretion of 63 Ni-NiCl2 administered orally to rats were studied by using liquid scintillation counting method. It was observed that the concentration-time curves in blood fitted the two compartment model of pharmacokinetics, Ka=6.18 h -1 , T 1/2 α=0.79 h, T 1/2 β=40.68 h, CL=0.42 mL·kg -1 ·h -1 , T max =0.53 h, C max =24 987.75 min -1 ·mL -1 , and Vd=0.016 L·kg -1 . After rats were treated by 63 Ni-NiCl2 for 15 days, in 22 tissues tested, the contents of 63 Ni-NiCl2 in hair, hypothalamus, hypophysis, pancreas, small and large intestines were higher, and the residua of 63 Ni-NiCl2 was not discovered in liver, kidney and heart. Radioactivity eliminated was 83.27% by urine and feces, 54.86% by urine, 28.41% by feces.
Absorption distribution and excretion of ^63 Ni-NiCl2 administered orally to rats were studied by using liquid scintillation counting method. It was observed that the concentration-time curves in blood fitted the two compartment model of pharmacokinetics, Ka=6.18 h^-1 , T1/2 α=0.79 h, T1/2 β=40.68 h, CL=0.42 mL·kg^-1 ·h^-1 , Tmax =0.53 h, Cmax =24 987.75 min^-1 ·mL^-1 , and Vd=0.016 L·kg^-1 . After rats were treated by ^63 Ni-NiCl2 for 15 days, in 22 tissues tested, the contents of ^63 Ni-NiCl2 in hair, hypothalamus, hypophysis, pancreas, small and large intestines were higher, and the residua of ^63 Ni-NiCl2 was not discovered in liver, kidney and heart. Radioactivity eliminated was 83.27% by urine and feces, 54.86% by urine, 28.41% by feces.
出处
《药学学报》
CAS
CSCD
北大核心
2008年第2期224-226,共3页
Acta Pharmaceutica Sinica
基金
国家自然科学人才培养基金资助[J0630962]
