绝经过渡期妇女睡眠质量与血清雌二醇、5-羟色胺的相关性研究

The Relationship between Serum Estradiol and Serotonin in Climacteric Women and Sleep Quality

目的：探讨绝经过渡期妇女睡眠质量与血清雌二醇（E2）、5-羟色胺（5-HT）的相关性。方法：采用匹兹堡睡眠质量指数问卷（PSQI）对吉林大学第二医院妇女保健门诊40—55周岁的绝经过渡期妇女进行睡眠质量的评价；采用病例对照方法，应用放免法和荧光法对绝经过渡期妇女睡眠质量差组（I组）、绝经过渡期妇女睡眠质量正常组（Ⅱ组）和生育年龄正常对照组（Ⅲ组）妇女各30例进行血清E2、5-HT水平的测定。结果：Ⅰ组的血清E2水平和5-HT水平低于Ⅱ组和Ⅲ组，且差异有显著性（P〈0．05）；绝经过渡期组血清5-HT与E2水平呈正相关性（r=0．025，P〈0．01）。结论：绝经过渡期妇女睡眠质量差的发生与血清E2及5-HT水平降低有关。

Objective：To study the relationship between serum levels of estradiol and 5 - HT and sleep quality in climacteric women. Methods：90 women aged between 40 - 55 years were randomly chosen from out- patients. Their sleep quality was evaluated by PSQI （the Pittsburgh sleep quality index）, and divided into three groups （30 cases in each group） ： poor sleep quality climacteric group （group Ⅰ ）, normal sleep quality climacteric group （group Ⅰ ） and normal sleep quality childbearing women group （group Ⅲ ）. The serum 5 - HTwas detected by irnmunofluorescence and the serum E2 （17beta- estradiol） level by radioimmunoassay. Results：The levels of serum E2 and 5 - HT in group I is lower than those in the other two groups（ P〈0.05）. The serum level 5- HT has positive relationship with that of E2 in two climacteric groups（r = 0.025, P〈0.01 ）.Conclusions：The climacteric women＇s poor sleep quality correlates with their lower level of serum E2 and 5 - HT.