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人脐血间充质干细胞对小鼠移植物抗宿主病治疗作用的研究 被引量：1

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摘要 近来对间充质干细胞（MSC）免疫学特征的研究显示了其在治疗移植物抗宿主病（GVHD）中良好的应用前景。我们建立了从人脐血中高效分离扩增MSC的方法。我们通过GVHD小鼠模型研究人脐血MSC对小鼠GVHD的作用，并探讨其可能机制，旨在为脐血MSC治疗GVHD的临床应用提供实验依据。
作者 吕璐璐 宋永平 魏旭东 张艳莉 房伯俊 李玉富 王姣杰
机构地区 河南省肿瘤医院血液科、河南省血液病研究所
出处 《中华血液学杂志》 CAS CSCD 北大核心 2008年第2期121-123,共3页 Chinese Journal of Hematology
关键词 脐血间充质干细胞 移植物抗宿主病 治疗作用 小鼠模型 GVHD 免疫学特征 高效分离 可能机制
分类号 R686 [医药卫生—骨科学]
  • 相关文献

参考文献5

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二级参考文献9

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共引文献37

同被引文献9

  • 1刘欣（综述）,孙自敏（审校）.异基因造血干细胞移植研究进展[J].国际移植与血液净化杂志,2007,5(1):10-14. 被引量：2
  • 2Rice AM, Wood JA , Milrose CG, et al . Conditions that enable human hematopoietic stem cell engraftment in all NOD-SCID mice[J]. Transplantation, 2000, 69 (5):927-935.
  • 3Kollet O, Peled A,Byk T,et al . Beta2 macroglobulin -deficient (B2m(null)) NOD/SCID mice are excellent recipients for studying human stem cell function[J]. Blood, 2000, 95(10): 3102-3105.
  • 4Atkinson K, Editor. Clinical Bone Marrow and Blood Stem Cell Transplantation: A Reference Textbook. 2nded. Cambridge, England: Cambridge University Press; 2000:111-146.
  • 5LulL, Liu YJ, Yang SG, et al. Isolation and charactetization of human umbilical cord mesenchymal stem cells with hematopoiesis-supportive function and other potentials[J]. Haematologica , 2006,91:1017-1026.
  • 6Margalit M, Ilan Y, Ohana M, et al. Adoptive transfer of small number of DX5^+ cells alleviates graft-versus-host disease in a murine model of semiallogeneic bone marrow transplantation: a potential role for NKT lymphocytes [J]. Bone Marrow Transplant ,2005, 35:191-197.
  • 7Bomstein R,Fiores AI, Montalan MA ,et al. Modified cord blood collection method achieves sufficient cell levels for transplantation in most adult patient [J]. Stem Cell , 2005,23: 324-334.
  • 8Wulf-Goldenbreg A, Eckert K, Fichtner I. Cytokine-pretreatment of CD34^+ cord blood sten cells in vitro reduces long-term cell engraftment in NOD/SCID mice[J]. Eur J Cell Biol,2007,[Epud ahead of print].
  • 9兰炯采,刘红雨,陈强,杨崇礼,武大林,张志梅.小鼠脐血移植模型研究[J].中华器官移植杂志,2000,21(4):253-253. 被引量：1

引证文献1

中华血液学杂志
2008年 第2期

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