微弧氧化法制备含铈羟基磷灰石生物活性膜层

Preparation and Properties of Cerium-containing Hydroxyapatite Coating on Commercially Pure Titanium by Micro-arc Oxidation

采用微弧氧化法在含有乙酸钙、β-甘油磷酸钠、硝酸铈的电解液中在纯钛金属表面原位生成了多孔含Ce羟基磷灰石生物涂层。用XRD、SEM、EDS、细胞培养等方法对膜层的厚度、物相、成分组成及生物相容性进行了研究。结果表明膜层粗糙多孔，厚度为15～25μm，与钛基体之间无明显界面；膜层表面主要物相为含Ce的羟基磷灰石；细胞培养结果表明膜层具有良好的生物相容性。

A porous cerium-containing Hydroxyapatite coating on commercially pure titanium was prepared by microarc oxidation （MAO） in the electrolytic solution containing calcium acetate,β-glycerol phosphate disodium salt pentahydrate （β-GP） and cerium nitrate. The thickness, phase, composition morphology and biocompatibility of the oxide coating were characterized by X-ray diffraction （XRD）, electron probe microanalysis （EPMA）, scanning electron microscopy （SEM） with energy dispersive X-ray spectrometer （EDS） and cell culture. The thickness of the MAO film was about 15-25μm, and the coating was porous and uneven, without any apparent interface to the titanium substrates. The results of XRD and EDX show that the porous coating was made up of HA film containing Ce. The favorable osteoblast cell affinity makes Ce-HA film a good bioeompatibility. Ce-HA film is expected to have significant medical applications as dental implants and artificial bone joints.