多孔ZrO_2-HA涂层复合材料的制备工艺

Preparation of Porous ZrO_2 Bone Scaffold Coated with Hydroxyapatite

采用凝胶成型法制备多孔氧化锆（ZrO2）支架，通过改变循环次数实现了对孔隙率的可控，使其保持在91％～45％之间，并且每循环一次，孔隙率稳定下降4～5％。在多孔ZrO2的表面涂覆羟基磷灰石（HA）涂层。为了防止HA和ZrO2之间的化学反应，中间涂覆了氟磷灰石（FA）层。XRD表明加了FA层作为中间层以后，没有发现反应发生。体视显微照片表明在HA／FA和FA／ZrO2两个界面上没有出现分层和裂纹，层与层之间结合紧密。

A novel technique that integrates the gel-casting technique with polymer sponge method to prepare ZrO2 porous scaffolds with controllable porosity （91%-45%） was reported. The pore morphology, ,size, and distribution of the scaffolds were characterized using an electron microscope. Porous ZrO2 was chosen as a framework for load-bearing and the HA was used as an outer coating layer to enhance the biocompatibility. To prevent the chemical reactions between ZrOz and HA, an intermediate fluorapatite （FA） layer was introduced. The coated HA/FA layer was firmly adhered to the ZrO2 body.