期刊文献+

RNA干扰用于抗HBV感染的研究进展

Progress in anti-HBV infection research by RNA interference
下载PDF
导出
摘要 乙型肝炎病毒(HBV)感染可引起急性和慢性乙型肝炎,最终可能导致肝硬化、肝癌等严重后果。作为一种可以帮助生物抵抗外在感染的体内防御机制,近年来RNA干扰已成为人们进行抗感染和基因治疗研究的有力工具。本文对RNA干扰技术在抗HBV感染方面的研究进展进行综述。 The infection of HBV may cause acute and chronic hepatitis B, and potentially lead to hepatocirrhosis and liver cancer. As a defense mechanism of organism to resist external infection, RNA interference (RNAi) has become a powerful tool for us to study its effects on antiviral infection and gene therapy in recent years. In this article we summarize the mechanisms of RNA interference and the progress on anti-HBV infection studies by RNAi.
出处 《基础医学与临床》 CSCD 北大核心 2008年第2期198-200,共3页 Basic and Clinical Medicine
基金 广东省科技攻关计划项目(2005B10401034)
关键词 乙型肝炎病毒 RNA干扰 基因治疗 HBV RNA interference gene therapy
  • 相关文献

参考文献9

  • 1Shlomai A, Shaul Y. Inhibition of hepatitis B virus expression and replication by R-NA interference [ J ]. Hepatology, 2003, 37 (4): 764 - 770.
  • 2Konishi M, Wu CH, Wu GY. Inhibition of HBV replication by siRNA in a stable HBV-producing cell line[ J]. Hepatology,2003,38 (4) : 842 - 850.
  • 3Chan DW, Ng IO. Knock-down of hepatitis B virus Xprotein reduces the tumorigenicity of hepatocellular carcinoma cells[J]. J Pathol, 2006,208(3) :372 -380.
  • 4潘修成,陈智,倪勤,羊正纲,徐宁,金晗英.tRNA^(val)-shRNA表达框在筛选HBV C基因小干扰RNA靶位中的应用[J].浙江大学学报(医学版),2006,35(2):154-160. 被引量:6
  • 5McCaffrey AP,Nakai H,Pandey K,et al. Inhibition of hepatitis B virus in mice by RNA interference[J]. Nat Biotechnol,2003,21 (6) :639 -644.
  • 6Giladi H, Ketzinel-Gilad M, Rivkin L, et al. Small interfering RNA inhibits hepatit- is B virus replication in mice [ J ]. Mol Ther, 2003, 8 (5) : 769 - 776.
  • 7应若素,范学工,朱才,李宁,章保新.RNA干扰在动物体内抗乙型肝炎病毒的效果[J].中华肝脏病杂志,2006,14(1):15-18. 被引量:6
  • 8Chen Ying, Du Dan, Wu Jun, et al. Inhibition of hepatitis B virus replication by stably expressed shRNA [ J ]. Biochem Biophy Res Commun,2003,311 (2):398 -404.
  • 9Chen CC, Ko TM, Ma HI, et al. Long-term inhibition of hepatitis B virus in trans-genic mice by double-stranded adeno-associated virus 8-delivered short hairpin RNA [J]. Gene Ther,2007,14( 1 ) :11 - 19.

二级参考文献13

  • 1倪勤,刘克洲,羊正纲,姚航平,爱德华,李敏伟,陈智.HBx-siRNA快速筛选体系的建立和应用[J].浙江大学学报(医学版),2004,33(4):300-305. 被引量:5
  • 2朱才,范学工,李宁,应若素.RNA干扰抑制乙型肝炎病毒复制的实验研究[J].中华肝脏病杂志,2004,12(9):522-525. 被引量:9
  • 3陈智.慢性乙型肝炎治疗的若干研究进展[J].浙江大学学报(医学版),2005,34(2):95-97. 被引量:3
  • 4徐宁,羊正纲,朱海红,姚航平,侯晓丽,吴炜.质粒介导的RNA干扰对AD293细胞中HBcAg表达的抑制作用[J].浙江大学学报(医学版),2005,34(2):104-109. 被引量:5
  • 5GOU D,JIN N,LIU L.Gene silencing in mammalian cells by PCR-based short hairpin RNA[J].FEBS Letters,2003,548:113-118.
  • 6CASTANOTTO D,LI H,ROSSI J J.Functional siRNA exprssion from transfected PCR products[J].RNA,2002,8:1 454-1 460.
  • 7KLEIN C,BOCK C T,WEDEMEYER H,et al.Inhibition of hepatitis B virus replication in vivo by nucleoside analogues and siRNA[J].Gastroenterology,2003,125:9-18.
  • 8CHEN Y,DU D,WU J,et,al.Inhibition of hepatitis B virus replication by stably expressed shRNA[J].Biochem Biophys Res Commun,2003,311:398-404.
  • 9KONISHI M,WU C H,WU G Y.Inhibition of HBV replication by siRNA in a stable HBV producing cell line[J].Hepatology,2003,38:842-850.
  • 10YANGZheng-gang CHENZhi NIQin etal(羊正纲 陈智 倪勤 ).Inhibition of HBs—GFP fusion gene expression by RNA interference[J].浙江大学学报:医学版,2005,34(2):1101-1101.

共引文献10

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部