α-羟基辛酸及其交酯的合成工艺改进

Process Improvement for the Synthesis of α-Hydroxyl Octanoic Acid and its Lactide

以正庚醛为原料,经过亲核取代、置换反应、酸水解及碱化脱氨等4步反应合成了制备3,6-二己基-1,4-二氧杂-2,5-二酮(辛交酯)的中间体——α-羟基辛酸(1);1经对甲苯磺酸催化脱水得辛交酯。改进并优化了合成工艺,1收率由58.0%提高至77.6%,辛交酯收率由65.0%提高至71.0%。

α-Hydroxyl octanoic acid （1） was synthesized from heptaldehyde by a four-step reaction of nucleophilic substitution, displacement reaction, acid hydrolysis and deaminization. 3,6-Dihexyl-1, 4-dioxane-2,5-dione（2） was prepared from I by dehydration using p-toluene suffonic acid as a catalyst. After synthetic method was improved and optimized the yields were increased from 58.0% to 77.6% for 1 and from 65.0% to 71.0% for 2, respectively.