流动注射化学发光测定盐酸丙卡特罗

Flow-Injection Chemiluminescence Determination of Procaterol Hydrochloride

发现盐酸丙卡特罗(Procaterol hydrochloride)在硫酸介质中能与铈(Ⅳ)和罗丹明B产生微弱的化学发光,而在该体系中加入盐酸和表面活性剂CTMAB,能显著增强化学发光的强度。探索了该化学发光体系最佳的反应条件,初步提出了该体系的反应机理,据此建立了流动注射化学发光测定盐酸丙卡特罗的新方法,线性响应范围为2×10-8g.mL-1～1×10-6g.mL-1,检出限为6×10-9g.mL-1;对2.0×10-7g.mL-1盐酸丙卡特罗连续11次平行测定的相对标准偏差为1.6%,该方法用于测定盐酸丙卡特罗片剂并与标准方法(中国药典法)比较,结果令人满意。

A new flow injection chemiluminescences method for the determination of procaterol hydrochloride has been developed. It is based on the chemiluminescence reaction of procaterol hydrochloride with Ce （Ⅳ）-rhodamine B in sulphuric-chlorhydric acid medium and the experimental fact of the enhancement of chemiluminescence by surfactant CTMAB. The concentration of the analyte shows a good linear relationship with the produced luminescence intensity in the range of 2. 0× 10^-8g·mL^-1 to 1.0×10^-6g·mL^-1. The detection limit of the proposed method is 6 ×10^-9g·mL^-1 and the RSD is 1.6% （n=11） at 2× 10^-7g·mL^-1. This result is satisfactory compared with the method mentioned in the pharmacopoeia of People＇s Republic of China.