产舒颗粒调节产后抑郁大鼠单胺类神经递质的作用机理研究

Effect Mechanism Research of Chanshu Granule on Neurotransum of the Postpartum Depression Modle Rats

目的探讨补虚化瘀中药产舒颗粒对产后抑郁大鼠单胺类神经递质的调节作用及其作用机理。方法动物造模后,观察产舒颗粒与其它用药组及模型组的动物脑组织中5-羟色胺(5-HT)、去甲肾上腺素(NE)和多巴胺(DA)含量的变化。结果用药30d后,阿米替林组、产舒颗粒14.0g生药/kg组及7.0g生药/kg组与模型组相比,5-HT含量明显升高;用药45d后,产舒颗粒7.0g生药/kg组5-HT含量较模型组明显升高;用药30、45d后各用药组NE、DA含量与模型组相近。结论产舒颗粒具有明显的抗抑郁作用。

Objective： To observe the adjustment effect of the Chanshu Granule which can supplement deficiency and resolvent stasis on the neurotransum of the postpartum depression modle rats and to explore its mechanism. Methods： Animals were made of postpartum depression modle. After given the Chanshu Granule, examined the concentration of 5 - hydroxytryptamine （5 - HT）, noradrenaline （NE） and dopamine （DA） of the postpartum depression modle rats at the 30th day and 45th day. Results： With postpartum depression modle at the 30th day the concentration of 5 - HT of Amitriptyline group, Chanshu Granule 14. 0g crude drugs/kg group and Chanshu Granule 7.0g crude drugs/kg group was increasd compared to modle group. At the 45th day the concentration of 5 - HT of Chanshu Granule 7.0g crude drugs/kg group was significantly increased compared to modle group. Amitriptyline group, Chanshu Granule 14.0g crude drugs/kg group and Chanshu Granule 7.0g crude drugs/kg group had no significant effect to the concentration of NE and DA at the 30th day and 45th day. Conclusion： Chanshu Granule has significant effect on anti postpartum depression.