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代谢综合征患者血浆脂肪细胞因子的观察 被引量：9

Observation of plasma adipocytokines in metabolic syndrome
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摘要 检测代谢综合征（MS）患者和正常对照人群血浆瘦素、纤溶酶原激活物抑制物1（PAI-1）、肿瘤坏死因子α（TNF-α）、游离脂肪酸（FFA）水平。结果发现瘦素、PAI-1、FFA是MS的独立危险因素，脂肪细胞因子可以部分解释肥胖与MS存在联系的原因。 Plasma leptin, plasminogen activator inhibitor-1 （PAI-1）, tumor necrosis factor-α （TNF-α） and free fatty acid （FFA） were assayed in patients with metabolic syndrome （MS）. The results showed that leptin, PAI-1 and FFA were independent risk factors of MS. The association of obesity and MS can be partially explained by adipocytokines.
作者 康国栋 郭志荣 胡晓抒 武鸣 周慧 陈冯梅
机构地区 苏州大学放射医学与公共卫生学院
出处 《中华内分泌代谢杂志》 CAS CSCD 北大核心 2008年第1期19-20,共2页 Chinese Journal of Endocrinology and Metabolism
基金 卫生部科学研究基金（WKJ2004-2-014）
关键词 脂肪细胞因子 代谢综合征 肥胖症 Adipocytokines Metabolic syndrome Obesity
分类号 R587.1 [医药卫生—内分泌] R589 [医药卫生—内分泌]
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参考文献9

  • 1Grundy SM, Brewer HB Jr, Cleeman JI, et al. American Heart Association, National Heart, lung, and Blood Institut: Definition of metabolic syndrome: Report of the National Herat, lung, and Blood Institute/American Heart Association conference on scientific issues related to definition. Circulation, 2004,109:433-438.
  • 2金文胜,潘长玉.国际糖尿病联盟关于代谢综合征定义的全球共识[J].中华内分泌代谢杂志,2005,21(4):412-413. 被引量：157
  • 3Matsuzawa Y. The metabolic syndrome and adipocytokines. FEBS Lett, 2006,580:2917-2921.
  • 4陈名道.脂肪细胞产物与肥胖和代谢综合征[J].中华内分泌代谢杂志,2003,19(3):161-163. 被引量：92
  • 5胡晓抒,郭志荣,周慧,史祖民,武鸣,张均,孙国祥,周正元,潘晓群,姚才良.江苏省35～74岁人群代谢综合征的流行病学调查[J].中华流行病学杂志,2006,27(9):751-756. 被引量：110
  • 6Lord GM. Leptin as a proinflammatory cytokine. Contrib Nephrol, 2006,151:151-164.
  • 7Matsushita K, Yatsuya H, Tamakoshi K, et al. Comparison of circulating adiponectin and proinflammatory markers regarding their association with metabolic syndrome in Japanese men. Arterioscler Thromb Vasc Biol, 2006,26:871-876.
  • 8Kanaya AM, Wassel Fyr C, Vittinghoff E, et al. Adipecytokines and incident diabetes meUitus in older adults: the independent effect of plasminogen activator inhibitor 1. Arch Intern Med, 2006,166 : 350- 356.
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二级参考文献23

  • 1周北凡,武阳丰,李莹,张林峰.中国成人代谢综合征腰围切点的研究[J].中华心血管病杂志,2005,33(1):81-85. 被引量：81
  • 2Flühbeck G, Gomez-Ambrosi J, Muruzabal FJ, et al. The adipocyte: a model for integration of endocrine and metabolic signalling in energy metabolism regulation. Am J Physiol Endocrinol Metab, 2001,280:E827-E847.
  • 3Karin M, Cao Y, Greten FR, et al. NF-Kappa B in cancer: from innocent bystander to major culprit. Nat Rev Cancer, 2002, 2:301-310.
  • 4Yang YS, Song HD, Li RY, et al. The gene expression profiling of human visceral adipose tissue and its secretory functions. Biochem Biophys Res Commun, 2003, 300:839-846.
  • 5Wiecek A, Kokot F, Chudek J, et al. The adipose tissue--a novel endocrine organ of interest to the nephrologist. Nephrol Dial Transplant, 2002,17 : 191-195.
  • 6Spranger J, Kroke A, Mohlig M, et al. Adiponectin and protection against type 2 diabetes mellitus, lancet, 2003, 361:226-228.
  • 7Kumada M, Kihara S, Sumitsyi S, et al. Association of hypoadiponectinemia with coronary artery disease in men. Arterioscler Thromb Vasc Biol, 2003,23:85-89.
  • 8Diez JJ, Iglesias P. The role of the novel adipocyte-derived hormone adiponectin in human disease. Eur J Endocrinol, 2003,148:293-300.
  • 9Scott MG,James IC,Stephen RD,et al.Diagnosis and management of the metabolic syndrome.An American Heart Association/National Heart,Lung,and Blood Institute Scientific Statement.Circulation,2005,112:2735-2752.
  • 10Gu D,Reyolds K,Wu X,et al.Prevalence of the metabolic syndrome and overweight among adults in China.Lancet,2005,365:1398-1405.

共引文献353

同被引文献124

引证文献9

二级引证文献35

中华内分泌代谢杂志
2008年 第1期

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