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脂联素与瘦素的比值和2型糖尿病胰岛素抵抗的相关性 被引量:8

Correlation between the ratio of adiponectin to leptin and insulin resistance in patients with type 2 diabetes
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摘要 在160例2型糖尿病患者分析脂联素与瘦素的比值(A/L)、稳态模型评估的胰岛素抵抗指数(HOMA—IR)和胰岛素抵抗参数的相关性。结果显示,在两性患者中,A/L和体重指数、腰臀比、甘油三酯、高密度脂蛋白胆固醇均显著相关。当空腹血糖逐渐升高时,A/L与胰岛素抵抗参数仍然相关,而HOMA—IR不再相关,提示A/L相对于脂联素、瘦素、HOMA—IR是一个较好评估胰岛素抵抗的指标。 [ Summary ] The correlation between parameters of insulin resistance and adiponeetin to leptin (A/L) ratio or homeostasis assessment for insulin resistance (HOMA-IR) was analyzed in 160 patients with type 2 diabetes. The results showed that A/L ratio was significantly correlated with body mass index, waist-to-hip ratio, triglyeerides and high density lipoprotein-eholesterol in both male and female patients, and significant correlation of these parameters except HOMA-IR with A/L ratio still existed as fasting plasma glucose level was gradually increased, suggesting that the A/L ratio was effective as a parameter of insulin resistance as compared with adiponectin, leptin, or HOMA-IR alone in patients with type 2 diabetes.
作者 刘师伟 杨静
出处 《中华内分泌代谢杂志》 CAS CSCD 北大核心 2008年第1期21-22,共2页 Chinese Journal of Endocrinology and Metabolism
关键词 脂联素 瘦素 胰岛素抵抗 糖尿病 2型 Adiponectin Leptin Insulin resistance Diabetes mellitus, type
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  • 2Taniguchi A, Fuknshima M, Ohya M, et al. Interleukin 6, adiponectin, leptin, and insulin resistance in no obese Japanese type 2 diabetic patients. Metabolism, 2006,55:258-262.
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