脂联素与瘦素的比值和2型糖尿病胰岛素抵抗的相关性

Correlation between the ratio of adiponectin to leptin and insulin resistance in patients with type 2 diabetes

在160例2型糖尿病患者分析脂联素与瘦素的比值（A／L）、稳态模型评估的胰岛素抵抗指数（HOMA—IR）和胰岛素抵抗参数的相关性。结果显示，在两性患者中，A／L和体重指数、腰臀比、甘油三酯、高密度脂蛋白胆固醇均显著相关。当空腹血糖逐渐升高时，A／L与胰岛素抵抗参数仍然相关，而HOMA—IR不再相关，提示A／L相对于脂联素、瘦素、HOMA—IR是一个较好评估胰岛素抵抗的指标。

[ Summary ] The correlation between parameters of insulin resistance and adiponeetin to leptin （A/L） ratio or homeostasis assessment for insulin resistance （HOMA-IR） was analyzed in 160 patients with type 2 diabetes. The results showed that A/L ratio was significantly correlated with body mass index, waist-to-hip ratio, triglyeerides and high density lipoprotein-eholesterol in both male and female patients, and significant correlation of these parameters except HOMA-IR with A/L ratio still existed as fasting plasma glucose level was gradually increased, suggesting that the A/L ratio was effective as a parameter of insulin resistance as compared with adiponectin, leptin, or HOMA-IR alone in patients with type 2 diabetes.