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研究胰岛β细胞量变化的方法学进展 被引量：1

Progress in the measurement and evaluation of islet β cell mass
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摘要 胰岛β细胞量（βcell mass）减少是1型或2型糖尿病的重要特征之一，确切检测和评估β细胞量具有重要意义。目前，胰腺组织学定量，分离后胰岛的定量和β细胞新生、增殖以及死亡的检测主要用于体外胰岛β细胞量测定研究；体内则利用β细胞分泌功能指标、正电子发射断层扫描（PET）的影像学技术进行间接评估，具有重要的应用价值。 Islet β cell loss plays an important role in the pathogenesis of type 1 and type 2 diabetes. Therefore, it is essential to measure or evaluate the β cell mass. Pancreas immunohistochemistry study, measurement of functional β cell mass after islet isolation, and β cell neogenesis, proliferation and cell death are mainly used in in vitro study. Islet β cell functional tests and positron emission tomography （PET） technique are the potential methods to evaluate β cell mass in vivo.
作者 宋静 贾伟平
机构地区 上海交通大学附属上海市第六人民医院内分泌代谢科
出处 《中华内分泌代谢杂志》 CAS CSCD 北大核心 2008年第1期88-90,共3页 Chinese Journal of Endocrinology and Metabolism
关键词 β细胞量 体外胰岛 β 细胞量测定 体内β细胞量评估 Islet β cell mass In vitro B cell mass measurement In vivo β cell evaluation
分类号 R587.1 [医药卫生—内分泌] R446.112 [医药卫生—诊断学]
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参考文献27

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二级参考文献74

共引文献156

同被引文献37

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中华内分泌代谢杂志
2008年 第1期

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