老年急性病毒性肝炎患者细胞免疫功能与肠源性内毒素血症的关系

The relationships between cellular immunity function and intestinal endotoxemia in elder patients with acute hepatitis

目的观察老年急性病毒性肝炎患者T细胞免疫功能与肠源性内毒素血症的关系。方法收集33例老年急性病毒性肝炎患者,检测肝功能、血浆内毒素(ET)和T淋巴细胞CD3^+、CD4^+、CD8^+亚群及CD4^+/CD8^+比例.分析CD细胞与ET的相关性。同时以33例中青年急性病毒性肝炎患者作为对照组。结果老年急性病毒性肝炎患者血ET水平明显高于中青年组(P<0.05),且CD4^+及CD4^+/CD8^+比例明显下降。血ET水平与CD4^+及CD4^+/CD8^+比例呈显著负相关。结论老年急性病毒性肝炎患者高内毒素血症的发生可能与T细胞免疫功能受损密切相关。

Objective To study the relationships between cellular immunity function and intestinal endotoxemia in elder patients with acute hepatitis. Methods 33 elder patients with acute hepatitis were selected to study and another 33 younger patients with acute hepatitis were observed as control. The blood from patients was collected for the measurement of endotoxin（ET） , peripheral blood T lymphocyte subset and liver function test. Results Plasma ET in the elders with acute hepatitis were significantly higher than that of the young group（P〈0.05）. The CD4^＋ T cell and CD4^＋/CD8^＋ in elder patients were lower than that of young patients group. There were negative correlations between ET and CD4^＋ T cell and CD4^＋/CD8^＋ in all patients. Conclusion Endotoxin is closely related to the status of immunoresponse in elder patients with acute hepatitis.