左旋肉碱和乙酰左旋肉碱复合制剂对特发性弱精子症精子质量的影响

Clinical Efficacy of Combined L-carnitine and Acetyl-L-carnitine on Idiopathic Asthenospermia

目的:观察左旋肉碱和乙酰左旋肉碱复合制剂对特发性弱精子症精子质量的影响。方法:采用自身对照实验设计。按WHO的标准诊断为特发性弱精子症的30例患者,经过中西医结合治疗无效后,服用左旋肉碱和乙酰左旋肉碱复合制剂,每次1袋,2次/d,疗程为3个月。应用本复合制剂前后按WHO标准进行精液分析各2次。结果:最终25例完成本观察。和治疗前比较,治疗后的精子存活率从(24.89±12.28)%提高为(49.45±17.40)%,精子活动力(a+b)级从(16.04±8.33)%提高为(24.64±7.09)%,一次射精的精子总数从(76.79±43.14)×106提高为(131.01±94.53)×106,有统计学显著差异(P<0.05)。结论:左旋肉碱和乙酰左旋肉碱对特发性弱精子症有辅助治疗效果,能提高患者的精液质量。

Objective： To evaluate the clinical efficacy of combined L-camitine and acetyl-L-carnitine on idiopathic asthenospermia. Methods ： Thirty patients with idiopathic asthenospermia were treated by combined L-camitine and acetyl-L-camitine for 3 months after failure to respond to the integrated therapy of Chinese and Western medicine. Semen samples were obtained, analyzed and graded according to the WHO laboratory manual before and after the treatment. Twenty-five of the patients completed the whole study. Results ： Combined L-carnitine and acetyl-L-camitine statistically improved the sperm vitality （24.89 ± 12.28） % , grade a ＋ b sperm motility （ 16.04 ± 8.33 ） % and the total sperm count per ejaculate （76.79 ± 43.14） × 10^6, with a significant difference from pre-treatment （P 〈 0.05 ）. Conclusion： Combined L-camitine and acetyl-L-carnitine has a supplementary effect in the treatment of idiopathic asthenospermia and improves the semen quality of the patient. Natl J Androi, 2008, 14 （2） ： 149-151