试论乳腺癌痰毒瘀结病机的理论基础与临床应用

Breast cancer pathogenesis of stagnation of phlegm,poison and blood stasis:rationale and clinical application in traditional Chinese medicine

乳腺癌在历代文献中被称为“乳岩”等,综合历代和现代医家论述,本文提出“毒邪”是贯穿乳腺癌发生、发展和转移始终的病因和病理产物,“六淫伏毒”和“七情郁毒”是乳腺癌发生的两大主要病因,“癌毒内生”是乳腺癌发生的核心变化,“痰毒瘀结”是乳腺癌发展的核心病机,“余毒未清”是术后的主要病机,“余毒旁窜”是术后复发转移的关键病机,“散结解毒”是术后抗复发转移治疗的重要治则。乳腺癌痰毒瘀结病机理论和散结解毒治则治法完善和发展了乳腺癌中医理论,具有一定的临床应用价值。

Breast cancer is called ＂Ruyan＂ in literature of traditional Chinese medicine. We synthesized the ancient and contemporary discussions and raised the theory that ＂Duxie＂ （poisonous pathogenic factor） is the etiological factor and pathologic product through the whole course of breast cancer. ＂Liuyin Fudu＂ （latent poison of six exogenous pathogenic factors） and ＂Qiqing Yudu＂ （stagnant poison of seven emotions） are the main etiological factors affecting the breast cancer occurrence. ＂Aidu Neisheng＂ （internal product of cancer poison） is the essential change in breast cancer occurrence. ＂Tandu Yujie＂ （stagnation of phlegm, poison and blood stasis） is the essential pathogenesis of the breast cancer’s development. ＂Yudu Weiqing＂ （vestigial poison） is the main pathogenesis of breast cancer after operation. ＂Yudu Pangcuan＂ （vestigial poison invasion elsewhere） is the key pathogenesis of recurrence and metastasis after operation. ＂Sanjie Jiedu＂ （dispersing accumulation and detoxification） is an important therapeutic principle in breast cancer’s treatment after operation. The ＂Tandu Yujie＂ pathogenesis theory and ＂Sanjie Jiedu＂ therapeutic principle developed the theory about breast cancer in traditional Chinese medicine, and have some clinical application value.