环氧化酶-2及其抑制剂，现在何处？又应走向何方？

COX-2 and COX-2 inhibitor, where are we? where do we go?

本文回顾环氧化酶-2(COX-2)抑制剂的发展史和分析新的筛选方法:如平衡抑制剂对COX-1/COX-2的选择性,寻找双靶点或多靶点的抑制剂。在计算机辅助药物设计中结合更多的灵活的动力学原理,在天然分子的基础上设计新的药物分子,辅以脂质体包裹剂型实现药物靶向投递,以图研究出新一代更为安全的COX-2抑制剂来预防、控制癌症和其他疾病。

This review is to discuss the COX-2 inhibitor screening from cell based bioassay and computer-based molecular docking technique towards more balanced inhibition of COX-I/COX-2, multiple-target inhibitors, and alternative choice of delivery, especially liposome encapsulated nanoparticles, in order to exploit new generation of safer COX-2 inhibitors for prevention and medication of cancer and other diseases.