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神经干细胞治疗阿尔茨海默病的研究进展 被引量：2

Neural stem cells: promising therapy for Alzheimer's disease
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摘要 神经干细胞(neural stem cell,NSCs)为阿尔茨海默病(Alzheimer’s disease,AD)神经系统的损伤修复和治疗提供了一个崭新的手段,具有广阔的应用前景。NSCs治疗AD的目的是修复和替代受损的神经细胞,重建细胞环路和细胞功能,主要通过两种途径:内源性途径,即诱导内源性NSC增殖与分化;外源性途径,即直接替代缺损组织或植入基因工程细胞,使受损伤的中枢神经系统修复。NSCs给AD的治疗带来了希望,如何诱导脑内的内源性NSCs增殖并分化为神经元形成功能网络是今后AD治疗的重要研究方向。 Neural stem cells offers a promising way for impairment and recovery of nervous system. Therapy for Alzeimer＇s disease by neural stem cells has two pathways： intrinsic pathway and extrinsic pathway. Intrinsic pathway induces proliferation and differentiation of neural stem cells. Extrinsic pathway transplants neural stem cells or genetically engineered cell into injuried tissue. NSCs bring new insights for Alzheimer＇s disease therapy. To control proliferation and differentiation of neural stem cells to set up neural functional network is an important rearch area for AD.
作者 蔡志友 晏勇 唐勇 王咏龙 吴芳
机构地区 重庆医科大学附属第一医院神经内科 重庆医科大学科研处
出处 《生命科学》 CSCD 2008年第1期90-94,共5页 Chinese Bulletin of Life Sciences
基金 重庆医科大学博士课题基金(2006010068)
关键词 阿尔茨海默病 神经干细胞 治疗 Alzheimer＇s disease neural stem cells therapy
分类号 R749.16 [医药卫生—神经病学与精神病学] Q813 [生物学—生物工程]
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参考文献25

  • 1Sarkis C, Serguera C, Petres S, et al. Efficient transducfion of neural cells in vitro and in vivo by a baculovirus-derived vector. Proc Nail Acad Sci USA, 2000, 97:14638-43
  • 2Buchet D, Buc-Caron MH, Sabate O, et al. Long-term fate of human telencephalic progenitor cells grafted into the adult mouse brain: effects of previous amplification in vitro. J Neurosci Res, 2002, 68:276-83
  • 3Marutle A, Ohmitsu M, Nilbratt M, et al. Modulation of human neural stem cell differentiation in Alzheimer (APP23) transgenic mice by phenserine. Proc Natl Acad Sci USA, 2007, 104(30): 12506-11
  • 4Fullwood NJ. Neural stem cells, acetylcholine and Alzheimer's disease. Nat Chem Biol, 2007, 3:435
  • 5Qu T, Brannen CL, Kim HM, et al. Human neural stem cells improve cognitive function of aged brain. Neuroreport, 2001, 12:1127-32
  • 6Kwak YD, Brannen CL, Qu T, et al. Amyloid precursor protein regulates differentiation of human neural stem cells. Stem Cells Dev, 2006, 15:1-9
  • 7赵志英,胡海涛,冯改丰,许杰华,张海英.人脑源性神经营养因子基因修饰神经干细胞移植对痴呆大鼠学习记忆的改善[J].中国修复重建外科杂志,2005,19(5):331-334. 被引量：24
  • 8Riaz SS, Theofilopoulos S, Jauniaux E, et al. The differentiation potential of human foetal neuronal progenitor cells in vitro. Brain Res Dev Brain Res, 2004, 153:39-51
  • 9Anton R, Kordower JH, Maidment NT, et al. Neural-targeted gene therapy for rodent and primate hemiparkinsonism. Exp Neurol, 1994, 127:207-18
  • 10Ahn TB, Kim JM, Kwon KM, et al. Survival and migration of transplanted neural stem cell-derived dopamine cells in the brain of parkinsonian rat. Int J Neurosci, 2004, 114:575-85

二级参考文献11

  • 1王德华,徐建光,姜浩,李继峰,汪洋,王劼,周国民,顾玉东.胚胎大鼠脊髓神经干细胞体外培养和分化的研究[J].中国修复重建外科杂志,2004,18(4):247-249. 被引量：6
  • 2Markowska AL,Olton DS, Givens B. Cholinergic manipulations in the medial septal area:age-related effects on working memory and hippocampal electrophysiology. J Neurosci,1995,15 (3):2063-2073.
  • 3Baskin DS,Browning JL, Pirozzolo FJ,et al. Brain chlorine acetyltransferase and mental function in Alzheimer disease. Arch Neurol ,1999,56(9) :1121-1123.
  • 4Shetty AK,Turner DA. In vitro survival and differentiation of neurons derived from epidermal growth factor-responsive postnatal hippocampus stem cells: inducing effects of brain-derived neurotrophic factor. J Neurobiol, 1998, 35(4):395-425.
  • 5Ebadi M,Bashir RM,Heidrick ML,et al. Neurotrophins and their receptors in never injury and repair. Neurochem Int, 1997,30(4-5):347-374.
  • 6Gray JA, Grigoryan G, virley D,et al. Conditionally immortalized multipotential and multifunctional neural stem cell lines as an approach to clinical transplantation. Cell Transplant, 2000,9(2) :153-168.
  • 7Martinez-Serrano A,Lundberg C,Horellou P,et al. CNS-derived neural progenitor cells for gene transfer of nerve growth factor to the adult rat brain :complete rescue of axotomized cholinergic neurons after transplantation into the septum. J Neurosci,1995,15(8) :5668-5680.
  • 8Frick KM, Baxter MG, Markowaska AL, et al. Age-related spatial reference and working memory deficits assessed in the water maze. Neurobiol Aging, 1995, 16(2) :149-160.
  • 9阮奕文,王传恩,童建尔,姚志彬.NGF/GDNF基因修饰神经干细胞移植对AD模型鼠行为学的疗效[J].解剖学报,2002,33(2):122-125. 被引量：14
  • 10朱晓峰,张晓梅,刘玉芳,徐忠烨,巢红艳,郑学胜.EGF、bFGF、BDNF对大鼠海马神经干细胞增殖和分化的作用[J].神经疾病与精神卫生,2002,2(6):389-389. 被引量：8

共引文献23

同被引文献16

  • 1刘新民,王圣平,于澍仁,王立为,肖培根,陈善广,宿双宁,邢智新.小鼠跳台的计算机自动管理系统[J].中国实验动物学报,1994,2(1):20-25. 被引量：3
  • 2Fu YS Cheng YC Lin MY Cheng H Chu PM Chou SC Shih YH Ko MH Sung MS.Conversion of human umbilical cord mesenchymal stem cells in Wharton＇s jelly to dopaminergic neurons in vitro： potential therapeutic application for Parkinsonism[J].中国生物学文摘,2006,20(10):22-23. 被引量：140
  • 3姚柏春,邓兆宏,孙天敏,黄翔,赵涓涓.Aβ_(1～40)诱导大鼠海马突触体素和突触数量的变化[J].中国现代医学杂志,2007,17(2):153-156. 被引量：19
  • 4Tsai K J, Tsai Y C, Shen C K. G-CSF rescues the mem- ory impairment of animal models of Alzheimer's disease [J]. J Exp Med, 2007, 204(6) :1273-1280.
  • 5Zachary L. Neuroprotective role of vascular endothelial growth factor: signaling mechanisms, biological function, and therapeutic potential [ J ]. Neurosignals, 2005, 14 ( 5 ) : 207-221.
  • 6Zheng C, Skold M K, Li J, et al. VEGF reduces astrogliosis and preserves neuromuscular junctions in ALS transgenic mice [ J 1. Biochem Biophys Res Comrnun, 2007, 363 (4) :989-993.
  • 7Jung K H, Chu K, Lee S T, et al. Granulocyte colonystimulating factor stimulates neurogenesis via vascular endothelial growth factor with STAT activation [J].Brain Res, 2006, 16:1073-1074.
  • 8Yankner B A, Lu T. Amyloid β-protein toxicity and the pathogenesis of Alzheimer' s disease [J ]. J Biol Chem, 2008,13 : 1-5.
  • 9Terry R D, Masliah E, Salmon D P, et al. Physical basis of cognitive alterations in Alzheimer' s disease: synapse loss is the major correlate of cognitive impairment [ J ]. Ann Neurol, 1991, 30(4) :572-580.
  • 10Shyu W C, Lin S Z, Yang H I, et al. Functional recover- γ of stroke rats induced by granulocyte colony stimulating factor stimulated stem cells [ J ]. Circulation, 2004, 110 ( 13 ) : 1847-1854.

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生命科学
2008年 第1期

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