摘要
目的探讨外源性肺泡表面活性物质（PS）预防新生儿呼吸窘迫综合征（NRDS）的临床疗效。方法将46例胎龄26～32wk、体重1000～1500g的早产儿随机分为两组，预防组出生后2h内气管内滴入PS，对照组不用PS，两组患儿均给予相同的综合治疗，比较两组NRDS的发生率、需要机械通气的比例、机械通气的时间及胸片改变的严重程度。结果预防组NRDS发生率，需要机械通气的比例及机械通气时间较对照组低，二者比较有统计学意义（P〈0．05）；预防组胸片改变程度比对照组轻。结论早产儿出生后预防性应用PS可以降低NRDS发生率，减轻NRDS发病程度。
Objective To probe into the clinical effect of exogenous pulmonary surfactant in prevention of neonatal respiratory distress syndrome （NRDS）. Methods Forty - six premature infants of gestational age of 26 -32 weeks and birth weight of 1000 - 1500g ,were randomly divided into therapeutic group and control group. Therapeutic group received PS via endotracheal tube within two hours after birth, and control group didn＇t. The same supportive treatments were given to both groups. The incidences of NRDS, rate and duration of mechanical ventilation and the severity of chest X - ray were compared between the two groups. Results The incidence of NRDS, rate and duration of mechanical ventilation in therapeutic group were significantly lower and shorter than that in control group （P 〈0.05 ） ; The severity of RDS on chest X -ray in therapeutic group was milder than that in control groups. Conclusion The prophylactic treatment with PS for premature infants can reduce the incidence of NRDS and decrease its severity.
