乙型肝炎病毒宫内感染相关因素随访研究

A Follow up Study on Correlated Factors for Intrauterine Infection of Hepatitis B Virus

为了探讨乙型肝炎病毒宫内感染的相关因素。对１２５例ＨＢｓＡｇ阳性孕妇及其婴儿进行了随访调查。按０、１、６方案对婴儿接种乙型肝炎疫苗，婴儿出生后２４小时内接种第一针疫苗时，同时注射乙型肝炎高效价免疫球蛋白。用酶联免疫吸附法检测孕妇及婴儿的ＨＢＶ感染指标。结果，共检出１３例婴儿血清中ＨＢｓＡｇ阳性，其中８例出生时即为阳性，５例为随访时阳转。宫内感染的发生率为１０．４％（１３／１２５）。单因素分析和ｌｏｇｉｓｔｉｃ多元回归分析表明，母亲ＨＢｅＡｇ阳性、先兆早产与宫内感染的发生有关。结论：母亲ＨＢｅＡｇ阳性、先兆早产是宫内感染的相关因素，其ＲＲ值分别为３１．２７和１０．８７。

One hundred and twenty two pregnant women with positive serum hepatitis B surface antigen (HBsAg) and their infants were followed up to study the risk factors related to intrauterine infection of hepatitis B virus (HBV). Infants were immunized with three doses of hepatitis B vaccine within 24 hours after birth, one month and six months of age, respectively, and hepatitis B immunoglobulin (HBIG) was injected simultaneously with the first dose. Markers of HBV infection in pregnant women and infants were detected by enzyme linked immunosorbent assay (ELISA). Results showed that 13 infants were detected positive for HBsAg in their sera, eight of them were positive at their birth and the other five converted positive during follow up. Simple and multiple logistic regression analyses showed that positivity of hepatitis Be antigen (HBeAg) in mothers and their threatened abortion related to intrauterine infection, with relative risks of 31.27 and 10.87, respectively.