工艺因素对超声-挤压过滤法制备β-榄香烯固体脂质纳米粒平均粒径的影响

Effect of the Technological Factors on the Mean Diameter of β-elemene Solid Lipid Nanoparticles Prepared by Sonication and Membrane Extrusion

目的研究工艺因素对β-榄香烯固体脂质纳米粒(SLN)平均粒径的影响。方法以超声-挤压过滤法制备β-榄香烯SLN,研究超声强度、超声时间以及制备温度等因素对其平均粒径的影响。结果绝大多数β-榄香烯SLN的平均粒径小于150 nm。其平均粒径随超声时间的延长和制备温度的提高而有所下降,但是受持续超声时间的影响较小。考察的制剂中,在超声强度为400W、超声温度为80℃、超声时间为6 min条件下制备的β-榄香烯SLN的平均粒径最小。结论采用超声-挤压过滤法可制备β-榄香烯SLN,超声强度、总体超声时间以及温度等是影响其平均粒径的主要工艺因素。

Objective To study the influence of the technological factors on the mean particle size of β - elemene solid lipid nanoparticles（ SLN ）. Methods β - elemene SLN were prepared by the method combining sonication and membrane extrusion. Effects of the technological factors on the mean particle size of β - elemene SLN were studied, including sonication strength, total period of sonication length and preparation temperature, etc. Results The results showed that most mean diameter of β - elemene SLNs was less than 150nm. The size of β - elemene SLN decreased with the increase of the total period of sonication length or the preparation temperature, but less influenced by the sonication interval length. Among the detection samples, smaller β - elemene SLN could be obtained at the sonication strength of 400w, with a total period of sonication length of 6min and at 80℃, respectively. Conclusion β - elemene SLN could be prepared by the method of sonication and membrane extrusion, the technological factors of sonication strength, total period of sonication length and preparation temperature have influence on the particle size.