摘要
以苯甲酸作起始原料，经溴化、Ｆｒｉｅｄｅｌ－Ｃｒａｆｔｓ反应、与丙二酸二乙酯催化偶合、甲基化、水解和脱羧制得酮洛芬，总收率为５１％。
Ketoprofen was synthesized from benzoic acid by bromination,Friedel Crafts reaction,catalytic coupling with diethyl malonate,methylation,hydrolysis and decarboxylation with 51% overall yield.
出处
《中国医药工业杂志》
CAS
CSCD
北大核心
1997年第9期387-388,共2页
Chinese Journal of Pharmaceuticals
关键词
酮洛芬
偶合反应
合成
ketoprofen,coupling reaction,synthesis
