皮肤细胞色素P450酶的研究进展

Advances in research on cytochrome P450 enzymes in skin

皮肤是肝外药物代谢的主要器官之一,有多种代谢酶表达。细胞色素P450酶(CYP)是一组含亚铁血红素的超家族基因编码的同工酶,皮肤CYP参与了多种内源性物质和外源性物质的代谢,在维持皮肤的正常生理功能和保护内环境稳定方面发挥重要作用。对皮肤CYP的研究有助于了解它在药物代谢和皮肤疾病中的作用,对提高药物疗效、开发经皮给药新制剂、防止药物和毒性物质对皮肤的侵害等,具有重要意义。

Skin is one of the main extrahepatic metabolic organs and expresses many kinds of metabolic enzymes. Cytochrome P450 enzyme（CYP） is an isoenzyme which is coded by a super-family gene and contains berne. It is involved in metabolizing both endogenous and exogenous substances and plays important roles in maintaining normal function of skin and the stability of internal environment. Study on skin CYP is conducive to well understanding skin diseases and drug metabolic process in skin, which has very important significance in enhancing drug efficacy, developing new percutaneous preparations and preventing toxic effects of drugs and toxicants on skin.