伏立康唑治疗恶性血液病侵袭性真菌病12例

Voriconazole in the treatment of invasive fungal disease in patients with hematologic malignancies: report of 12 cases

目的观察伏立康唑治疗恶性血液病患者侵袭性真菌病的疗效。方法以伏立康唑治疗12例诊断为侵袭性真菌病的恶性血液病患者,观察疗效及不良反应。结果12例患者中,有效7例,其中完全反应3例,部分反应4例。1例出现视觉模糊,1例出现转氨酶升高,1例出现低钾血症。结论伏立康唑是治疗恶性血液病患者侵袭性真菌病的高效及安全的药物。

Objective To evaluate the efficacy and safety of voriconazole for invasive fungal disease （IFD） in patients with hematologic malignancies. Methods Twelve patients with hematologic malignancies complicated with IFD were treated with voriconazole to understand the efficacy and adverse effect. Results Good responses were seen in 7 patients （58.3%）; 3 patients （25 % ） showed complete response and 4 （33.3 % ） partial response, Visual disturbance, elevated liver function test and kaliopenia were reported in one patient each, Conclusions Voriconazole is efficacious and safe in the treatment of IFD patients with hematologic malignancies.