肿瘤抑制基因PTEN在乳腺癌中的表达及其临床意义

Significance and expression of PTEN in breast cancer

目的研究肿瘤抑制基因PTEN在乳腺癌组织中的表达及临床意义。方法采用免疫组化法检测83例乳腺癌组织PTEN蛋白的表达情况。结果83例乳腺癌组织的PTEN阳性表达率为61.4%(51/83),PTEN阴性表达率为38.6%(32/83)。PTEN表达与乳腺癌原发肿瘤的大小(P<0.05)、临床分期(P<0.05)、淋巴结转移(P<0.05)以及雌激素受体(ER)(P<0.05)有关。PTEN高表达的乳腺癌患者5年总生存率明显高于低表达者(P<005)。结论乳腺癌组织中存在肿瘤抑制基因PTEN的表达缺失或减弱,可能与乳腺癌的发生、发展有关。PTEN可以作为一个判断乳腺癌预后的指标。

Objective To investigate the expression of PTEN in breast cancer and its clinical significance.Methods Immunohistochemical method was used to detect the expression of PTEN in 83 cases of breast cancer.Results The positive percentage of PTEN expression was 61.4%（51/83）in patients with breast cancer,negative percentage was 38.6%（32/83）.The expression of PTEN was closely related to tumor size（P〈 0.05）,clinical stage（P〈0.05）and expression of ER（P〈0.05）of breast cancer.The overall 5 year survival rate of patients with PTEN high expression was superior to those with low expression（P〈0.05）.Conclusion This study suggests that tumor suppressor gene PTEN is abnormally expressed in breast cancer.PTEN probably plays an important role in tumorigenesis and development of breast cancer.PTEN may be used as a marker for prediction of the prognosis of patients with breast cancer.