血清总胆汁酸测定在肝胆疾病诊断中的应用

The significance of detection of serum total bile acids in diagnosis of hepatobiliary diseases

目的探讨胆汁酸(TBA)在诊断肝胆疾病中的临床价值。方法采用循环酶速率法检测了140例病人,其中37例急性肝炎患者,45例慢性肝炎患者,20例肝硬化患者,25例肝癌患者,13例胆管阻塞患者。并与62例健康对照组的血清总胆汁酸含量进行比较。结果各类肝胆疾病患者TBA均显著高于健康对照组(P<0.01),其中TBA的阳性率在急性肝炎组?肝硬化组及肝癌组均(80%。结论TBA检测简便实用,对肝胆疾病的临床诊断有重要的临床意义。

Objective To investigate the clinical significance of detection of serum total bile acids（TBA）in diagnosis of hepatobiliary diseases.Methods Serum level of TBA was determined by kinetic method in 140 patients（37 cases of acute hepatitis,45 cases of chronic hepatitis,20 cases of liver cirrhosis,25 cases of liver cancer and 13 cases of obstruction in bile ducts）and 62 healthy controls.Results The serum levels of TBA in above-mentioned patients were significantly higher than those of healthy controls（P〈0.01）.The positive rates of raised level of TBA in patients with acute hepatitis,liver cirrhosis and liver cancer were over 80%.Conclusion Detection of serum level of TBA is a simple and practicable method for diagnosis of hepatobiliary diseases with important clinical significance.