3项检测对非ST段抬高的急性冠状动脉综合征的诊断价值

Clinical value of three indices detection in diagnosis of non-ST segment elevated acute coronary syndrome

目的探讨心肌肌钙蛋白I、血栓前体蛋白和脑钠肽对非ST段抬高的急性冠状动脉综合征(ACS)的诊断价值。方法将60例非ST段抬高的ACS患者分为非ST段抬高心肌梗死组(NSTEMI组)和不稳定型心绞痛组(UA组)。分别测定症状发作6h内及24h的心肌肌钙蛋白I(cTnI)、血栓前体蛋白(TpP)和脑钠肽(BNP),并设30例对照组比较。采用夹心酶联免疫法测定cTnI、TpP浓度。采用放射免疫吸附法测定血浆BNP浓度。结果NSTEMI组与UA组的cTnI、BNP和TpP差异有统计学意义(P<0.05或P<0.01)。结论cTnI、BNP和TpP在非ST段抬高ACS诊断中有重要价值。

Objective To evaluate the clinical diagnostic value of cardiac troponin I （cTnI）, thrombus precursor protein （TpP） and brain natriuretic peptide （BNP） detection in non-ST segment elevated acute coronary syndrome （ACS）. Methods Thirty healthy people （control group） and sixty patients with non ST segment elevated acute coronary syndrome Edivided into non-ST segment elevated myocardial infarction （NSTEMI） group and unstable angina pectoris （UA） group] were enrolled in the study. At 6 h and 24 h time-points after onset, cardiac troponin Ⅰ （cTnI）, thrombus precursor protein （TpP） and brain natriuretic peptide （BNP） were detected. Sandwich enzymelinked immunosorbent assay was applied to measuring serum levels of cTnI and TpP;radioimmunosorbent assay applied to measuring plasma level of BNP. Results The differences of cTnI, BNP and TpP were statistically significant （P〈0.05 or P〈0.01）. Conclusion cTnI, BNP and TpP contributeto the diagnosis of non-ST segment elevated acute coronary syndrome.