新疆和田地区结核病耐药监测调查

Analysis of Drug Resistance of Tuberculosis in Hotan Area of Xinjiang

目的监测结核分枝杆菌的耐药情况,获得初始耐药、获得性耐药及耐多药资料,评价新疆部分地区的结核病控制工作。方法采用WHO/IUATLD《结核病耐药监测指南》要求的整群抽样方法及WHO推荐的比例法进行药敏试验,由WHO结核参比试验室质控菌株进行质控。结果和田地区入选病例224例,对4种抗结核药物(INH,RFP,SM,EMB)的耐药性进行了测试。总耐药率为32.6%(73/224),初始耐药率为33.2%(64/193),获得性耐药率为29%(9/31),耐多药率为4%(9/224)。结论新疆的结核分枝杆菌的耐药率依然很高,结核病控制工作不容忽视。

Objective To survey drug resistance of Mycobacterium tuberculosis, obtain the data of initial, acquired and multi - drug resistance, evaluate tuberculosis control in part areas of Xinjiang. Methods According to the Guidelines for Surveillance of Drug Resistance in Tuberculosis of WHO/IUATLD, cluster sampiing and the proportion method recommended by WHO were taken to carry out susceptibility test. Laboratory quality control was conducted with other reference laboratory. Results Two hundred and twenty - four cases from Hotan area were selected to test drug resistance to INH, RFP, SM and EMB with the total drug resistance rate of 32.6%, the initial drug resistance rate of 33.2%, the acquired drug resistance rate of 29% and the multi - drug resistance rate of 4%. Conclusions The rate of drug resistance of Mycobacterium tuberculosis is still high, and tuberculosis control can not be ignored.