多功能聚合物胶束的最新研究进展

Progress in multifunctional polymeric micelles

由两亲性聚合物形成的胶束是一种很有发展前景的纳米级药物载体。聚合物胶束作为药物载体具有许多优势,如载药能力强、粒径小、体内循环时间长、具有主动和被动靶向性等特点。聚合物胶束的最新研究主要集中在使其功能更加完善方面,即多功能聚合物胶束的研究。现按照多功能聚合物胶束到达目标部位后发挥效用的方式对其进行分类,并对其最新研究进展和应用进行综述。

Polymeric micelles self-assemblied by amphiphilic block copolymers in aqueous media are thought to be promising drug carriers with nanometer size. Polymeric micelles possess several advantages as compared with other drug carriers, such as high loading capacity, small particle size, long-circulation time, targeting ability and so on. Recently, the research for polymeric micelles has been focused on the combination of the above properties to construct multifunctional polymeric micelles. This review highlights the recent progress in muhifunctional polymeric micelles, including the classification and their applications.