癌基因c-erb B-2在结肠血吸虫病并发肠癌和肠息肉中的表达及AgNOR观察

EXPRESSION OF C ERB B 2 ONCOGENE AND OBSERVATION OF AgNOR ON COLONIC CANCER AND POLYP WITH CHRONIC COLONIC SCHISTOSOMIASIS

目的：探讨肠道血吸虫病与肠癌发生的关系。方法：应用免疫组织化学ＬＳＡＢ法对结肠血吸虫病并发结肠癌、肠息肉和无血吸虫病的肠癌、肠息肉行ｃｅｒｂＢ２标记并ＡｇＮＯＲ染色。结果：肿瘤细胞中癌基因ｃｅｒｂＢ２表达呈明显异质性；血吸虫病并发肠癌与无血吸虫病的肠癌表达阳性率，两者之间无明显差异（Ｐ＞００５）；血吸虫病肠息肉的表达明显高于无血吸虫病的肠息肉（Ｐ＜００５）。血吸虫病肠息肉ＡｇＮＯＲ／核均显著高于无血吸虫病的肠息肉（Ｐ＜００５）；血吸虫病且ｃｅｒｂＢ２阳性肠息肉和无血吸虫病肠癌之间ＡｇＮＯＲ／核均数无显著差异（Ｐ＞００５）。结论：肠癌中ｃｅｒｂＢ２阳性者具有较强浸润转移能力，血吸虫病肠息肉且ｃｅｒｂＢ２阳性者有癌前病变特征，血吸虫病肠息肉和并发肠癌恶性潜能高。

cases of colonic cancer and polyp with chronic colonic schistosomiasis and 20 cases of colonic cancer and polyp with non-schistosomiasis were labeled by C erb B 2 and stained by AgNOR. C erb B 2 positive rate of colonic cancer with schistosomiasis was 33 3% and 30 0% for non-schistosomasis. C erb B 2 positive rate of colonic polyp with schistosomiasis was 41 7% while 10% in non-schistosomiasis. The difference between two groups was highly significant (P<0 05) . Average of AgNOR nuclear particle of colonic polyp was 3 52±1 22 in schistosomiasis group and 2 47±0 89 in non-group (P<0 05) . It suggests that schistosome infection causes damage to colonic mucosa and stimulates grandular epithelium for proliferation. So, it presents highly latent malignancy.