大鼠急性坏死性胰腺炎中肠道细菌移位的致病作用

THE ENTERIC BACTERIAL PATHOPOIESIS IN RAT ACUTE NECROTIC PANCREATITIS

目的：探讨急性坏死性胰腺炎（ＡＮＰ）细菌感染的来源和规律。方法：采用大鼠制成急性胰腺炎（ＡＰ）动物模型，分别于２４和７２小时取胰腺组织及盲肠、肠系膜淋巴结、胆汁、血液作细菌学培养和病理检查评分。结果：实验组胰腺病变严重，而对照组无明显病变；实验组病理评分明显高于对照组，两组比较有显著性差异（Ｐ＜００１）；实验组细菌培养阳性率高，大多为肠道细菌。结论：ＡＰ时肠道细菌可移位至胰腺，病变重细菌移位率越高；肠系膜淋巴结、胆道是肠道细菌发生移位的重要途径。

The rat acute pancreatitis (AP) was used as animal model to study infection origination and patern of acute necrotic pancreatitis (ANP). The 24 hour’s and 72 hour’s specimen from pancrea tissue, cecum and mesenteric lymph nodes, bile, blood were drawn for check. Results: Experimental group had more serious damaged pancrea and higher pathological rating scale than control group (P<0 01) . The positive rate for bacterial culture (most were enteric bacteria) was high in experimental group. It is concluded that enteric bacteria can move to pancrea; The severer the disease is, the more bacteria move to; Mesenteric lymph nodes and biliary tract are the important ways for bacteria to move.