氟哌啶、东莨菪碱和异丙嗪分别硬膜外腔给药对吗啡镇痛期副作用的影响

EFFECT OF DROPERIDOLUM, SCOPOLAME AND PHENERGAN TAROUGH EPIDURAL ADMINISTRATION ON SIDE EFFECTS PRODUCED BY MORPHINE FOR ANALGESIA

目的：观察氟哌啶、东莨菪碱和异丙嗪减少吗啡镇痛期副作用的效果。方法：１００例手术病人分四组。经硬膜外腔分别给药，记录术后疼痛及副反应。结果：氟哌啶、东莨菪碱及异丙嗪组恶心、呕吐、瘙痒发生率均低于单纯吗啡组，有显著差异；其中氟哌啶组恶心、呕吐，异丙嗪组瘙痒发生率最低，且异丙嗪组的镇痛时间最长。各组对尿潴留的发生率无影响，亦未见明显的毒性反应。结论：氟哌啶、东莨菪碱和异丙嗪均能减轻吗啡所致的恶心、呕吐、瘙痒，又不影响吗啡的效价。其中异丙嗪作用最佳，不仅抗瘙痒作用最强，且能延长吗啡的镇痛时间。

patients were divided into four groups and respectively received therapy of droperidolum, scopolamine and phenergan through epidurala dministration while using morphine for analgesia. The side effects and efficacy of analgesia were recorded. Results: frequency of nausea, vomiting and itching was reduced in droperidolum group, scopolaming group and phonergan group compared to single use of morphine. The droperidolum group had the least frequency of nansea and vomiting while phenergan group had the least frequency of itching and prolonged effect of analgesia. All groups had no side effect of urine retention and toxic reaction. Conclusion: droperidolum, scopolamine and phenergan can relief nausea, vomiting and itching produced by morphine, but no influence on it efficacy. Phenergan results the best by strong antipruritic effect and prolonged analgesic effect.