摘要
目的：观察黄芪注射液配合泼尼松治疗肾病综合征的疗效。方法：应用黄芪注射液配合泼尼松治疗肾病综合征４３例，并观察治疗前后血浆白蛋白水平、２４小时尿蛋白定量、尿纤维蛋白降解物（ＦＤＰ）、血尿素氮、血肌酐、总胆固醇、甘油三酯及血红细胞超氧化物歧化酶（ＲＢＣＳＯＤ）、还原型谷胱甘肽（ＧＳＨ）和丙二醛（ＭＤＡ）的变化。结果：４３例中治愈１８例，好转１５例，未愈１０例，总有效率为７６．７％。治疗后２４小时尿蛋白定量、尿ＦＤＰ、血尿素氮、血肌酐、总胆固醇、甘油三酯和ＭＤＡ均显著下降（Ｐ＜０．０５～０．０１），而血浆白蛋白、ＲＢＣＳＯＤ和ＧＳＨ均明显增高（Ｐ＜０．０５～０．０１）。结论：黄芪注射液配合泼尼松治疗肾病综合征，可改善肾功能，减少尿蛋白，提高血浆白蛋白水平，并有降低血脂及缓解肾小球高凝状态和抗氧自由基的作用。
Objective:To observe the therapeutic efficacy of astragalus injection cooperated by prednisone in treating nephrotic syndrome.Methods:Fortythree cases of nephrotic syndrome were treated with astragalus injection and prednisone.In addition,the changes of plasma albumin concentration,urinary protein quantity for 24 hours,urinary fibrin degradation products (FDP),blood urea nitrogen (BUN),blood creatinine (Cr),total cholesterol,triglyceride,superoxide dismutase in erythrocyte (RBCSOD),reduced glutathione(GSH) and malondialdehyde (MDA) were detected before and after treatment.Results:Eighteen cases were cured,15 cases were improved,10 cases were no improved,the total effective rate was 76 7%.The levels of urinary protein quantity for 24 hours,FDP in urine,BUN,Cr,total cholesterol,triglycerides and MDA were obvious decreased after treatment ( P <0 05～0 01),but the levels of plasma albumin,RBCSOD and GSH were obvious increased ( P <0 05～0 01).Conclusions:Astragalus and cooperated by prednisone treating nephrotic syndrome can improve the renal function,reduce urinary protein,raise serum albumin quantity,decrease blood lipid level,relieve glomerular hypercoagulable state and clear the free oxygen radicals.
