摘要
Objective： To investigate the expressions of atypical protein kinase C = subtype （aPKC-I and E-cadherin in cholangiocarcinoma, and analyze molecular mechanisms of the invasion and metastasis of cholangiocarcinoma. Methods： The expressions of aPKC-I nd E-cadherin in 9 specimens of benign bile duct tissues and 35 specimens of cholangiocarcinoma were detected by EnVision immunohistochemistry, and their correlations to the clinicopathologic characteristics and invasion of cholangiocarcinoma were analyzed. Results： The positive rate of aPKC-I was significantly higher in cholangiocarcinoma than in benign bile duct tissues （68.6% vs. 11.1%, P = 0.006）, while the positive rate of E-cadherin was significantly lower in cholangiocarcinoma than in benign bile duct tissues （37.1% vs. 88.9%, P = 0.016）. aPKC-I expression was negatively correlated to E-cadherin expression （r = -0.287, P 〈 0.05）. aPKC-I expression was positively and E-cadherin expression was negatively correlated to the differentiation and invasion of cholangiocarcinoma （P 〈 0.05）. Conclusion： The expressions of aPKC-I and E-cadherin may reflect the differentiation and invasive potential of cholangiocarcinoma. As a polar regulation-associated protein, aPKC-I may play an important role in the invasion and metastasis of cholangiocarcinoma.
基金
Supported by a grant from the National Natural Sciences Foundation of China (No. 30672040)
