氯胺酮诱导不同年龄和性别小鼠的过度活动(英文)

Ketamine-induced hyperactivity in mice: an evaluation of age and sex differences

虽然氯胺酮(Ketamine)在历史上作为麻醉剂用于人类和家畜,但由于其分解特性,作为一种娱乐药物似乎更具知名度。以前的研究表明相对于成年人,孩子使用氯胺酮不易显示出不利影响,但是对其发生的机理几乎没有研究。本文研究了氯胺酮对小鼠的活动程度和固有行为的作用。结果表明:使用氯胺酮可增加22、35和50日龄小鼠的运动器官的敏捷性,并证明了氯胺酮的作用随年龄的增长而降低;使用氯胺酮所导致的旋转与年龄的变化有关,但站立的减少与年龄无关,这种减少不依赖于小鼠的年龄。

Although ketamine has historically been employed as an anesthetic for human and veterinary uses, it appears to be gaining popularity as a recreational drug based upon its dissociative properties. Additionally, previous research indicates that children are less likely to show adverse effects of ketamine administration compared to adults, but few studies have examined these developmental trends. The current study was conducted to investigate potential age-and sex-related effects of ketamine on activity levels and stereotypic behaviors in mice. We reported increases in locomotor activity with administration of ketamine in 22-, 35-, and 50-day-old mice and showed that the effects of ketamine diminish with age. We also reported age-related changes in turning as a result of ketamine administration and decreases in rearing, which were not age dependent, following administration of the drug. Results are consistent with the idea that two independent mechanisms （i. e., N-methyl-D-aspartate and dopamine） are responsible for the current findings