国产盐酸吡格列酮治疗代谢综合征的研究

Clinical effects of pioglitazone hydrochloride in patients with metabolic syndrome

目的:探讨国产胰岛素增敏剂盐酸吡格列酮对代谢综合征的治疗作用。方法:对45例确诊的代谢综合征患者,在饮食控制的基础上使用盐酸吡格列酮治疗12周,观察治疗前后腰围(WC)、空腹胰岛素抵抗指数(HOMA-IR)、空腹血糖(FBG)、甘油三酯(TG)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、血压(BP)等指标的变化。结果:治疗12周后,患者HOMA-IR、FBG、TG、LDL指标较治疗前均显著下降。结论:盐酸吡格列酮可降低胰岛素抵抗、改善糖、脂代谢,对代谢综合征具有治疗作用。

Objective ： To investigate the effects of Pioglitazone Hydrochloride in patients with metabolic syndrome（MS）. Methods： Forty-five patients with diagnosed MS were enrolled and administrated with Pioglitazone Hydrochloride for 12 weeks. A serial indexes of waist circle（ WC）, the homeostasis model assessment of insulin resistance （HOMA-IR）, fast blood glucose （FBG）, serum lipid （TG, TC, HDL-C, LDL-C） and BP were measured before and after treatment. Results ： The level of HOMA--IR, FBG, TG, TC and LDL-C significantly decreased with Pioglitazone Hydrochloride （ P 〈 0.05）. The levels of WC, HDL-C and BP had no significantly changed. Conclusion： Pioglitazone Hydrochloride can modify the metabolic process of lipid and glucose and has therapeutic effects on MS.