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基因多态性与阿司匹林抵抗 被引量：1

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摘要 目前发现,促血栓形成性基因变异可能促进阿司匹林抵抗,增加心血管事件的风险。这些基因多态性主要包括:①编码环氧合酶1的基因多态性;②编码血小板膜糖蛋白Ⅲa的血小板抗原1/血小板抗原2多态性;③编码血小板膜糖蛋白Ⅰa/Ⅱa的807C/T和873G/A多态性。通过基因多态性的检测不仅有助于阐明阿司匹林抵抗的发生机制,同时也为患者选择合理有效的药物疗法、实现治疗策略的个体化以及临床转归的评估提供理论基础。
作者 苏冠华 肖玮 陈欣 王朝晖
机构地区 华中科技大学同济医学院附属协和医院心血管病研究所
出处 《中国动脉硬化杂志》 CAS CSCD 2007年第11期876-878,共3页 Chinese Journal of Arteriosclerosis
关键词 药理学 阿司匹林抵抗 遗传多态性 血小板膜糖蛋白 环氧合酶 冠状动脉疾病
分类号 R96 [医药卫生—药理学]
  • 相关文献

参考文献23

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共引文献4

同被引文献24

  • 1赵丽筠,谢思勤,王炜.口服小剂量阿司匹林致上消化道出血141例的文献分析[J].海南医学,2005,16(3):102-103. 被引量：5
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中国动脉硬化杂志
2007年 第11期

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