新疆维吾尔族非霍奇金淋巴瘤的临床病理特点

Clinicopathological feature of non-Hodgkin′s lymphoma in Xinjiang Uygur

目的:应用2001年世界卫生组织(WHO)造血淋巴组织学新分类,探讨并分析新疆维吾尔族非霍奇金淋巴瘤(NHL)的临床病理特点。方法:收集93例新疆维吾尔族NHL病例,重新复检HE切片,应用免疫组织化学P-V9000二步法标记CD20、CD45RO、CD30、CD15抗体,结合临床病理特征及免疫组织化学染色结果进一步分型。结果:93例新疆维吾尔族NHL病例男女比例为1.91∶1;发病平均年龄44.54岁;发病部位结内54例(54/93,58.06%),结外39例(39/93,41.94%),B细胞性淋巴瘤76例(76/93,84.3%),占绝对优势;最常见组织学类型为弥漫性大B细胞淋巴瘤43例(43/93,46.24%)。结论:新疆维吾尔族NHL的发病年龄相对较年轻,男性多于女性;发病部位结内多见;最常见组织学类型依次为弥漫性大B细胞淋巴瘤、滤泡性淋巴瘤、粘膜相关淋巴组织的结外边缘区B细胞淋巴瘤。

Objective： To study the clinicopathological feature of non-Hodgkinrs lymphoma （NHL） in Xinjiang Uygur, application of the 2001 World Health Organization （WHO） classification of lymphoid neoplasms. Methods： Ninety-three cases of Xinjiang Uygur with NHL were reviewed by pathologists to identified the diagnosis and subtype, combining the results of immunohistochemistry （IHC） stain. Results： Clinicopathologic features： there were 61 cases of males and 32 cases of females in 93 in Xinjiang Uygur NHL, the ration of sex was 1. 91： 1, the average age was 44. 54 years old; There were 54 cases （54/93, 58.06%） in lymph node, 39 cases （39/93, 41.94%） in extra-node. The most common subtype was diffuse large B cell lymphoma （DLBCL 43/93, 46.24%）. Conclusions： Comparing with other reports, the average age of Xinjiang Uygur NHL was younger, the cases of male was more than those of female; There were more cases in lymph node than in extra node, and the most common subtypes were DLBCL, FL and MALT.