三维适形放疗治疗局部进展期非小细胞肺癌疗效分析

Effect analyzed on three dimensional conformal radiationtherapy for local progressive non-small lung cancer

目的：研究三维适形放射治疗局部进展期非小细胞肺癌（NSCLC）的疗效和毒副作用。方法：56例局部进展期非小细胞肺癌患者均采用三维适形放疗,先行计划靶区（PTV）照射45-50 Gy,后缩野肿瘤区（GTV）加量照射累积剂量DT61-67 Gy,均为1.8-2.0 Gy/次,5次/周。结果：完全缓解（CR）17例（30.4%）,部分缓解（PR）32例（57.1%）。1年生存率75.0%,2年生存率33.9%。毒副作用以放射性食管炎及放射性肺炎为主,但均可耐受。结论：三维适形放疗可提高局部进展期非小细胞肺癌患者局控率及1、2年生存率,减轻放疗的毒副作用。

Objective： To evaluate the effect and toxicity of 3-dimensional eonformal radiation therapy （3DCRT） in treating local progressive non-small lung cancer （NSCLC）. Methods： Fifty-six patients with local progressive non-small lung cancer were radiated by 3DCRT. They first receive 45-50 Gy to PTV, then boosted to GTV to a total dose DT 61-67 Gy. They all were executed at 1.8-2.0 Gy/fraction, 5 fraction/weekl Result： There were 17 cases of CR （30.4%） and 30 cases of PR （57.1%）. The overall 1, 2 year survive rates were 75.0% and 33.9% respectively. Serious toxicity was found to be the radiation esophagitis and radiation pulmonitis, but tolerable. Conclusion： 3DCRT could enhance the local control rate and 1, 2 year survive rate of local progressive NSCLC and reduce serious radiation toxicity.