重组组织型纤溶酶原激活剂静脉溶栓治疗急性心肌梗死后的QT离散度变化

Changes of QTcd during thrombolytic therapy of acute myocardial infarction with recombinant tissue-type plasminogen activator

３６例急性心肌梗死患者接受重组组织型纤溶酶原激活剂（ｒｔ－ＰＡ）静脉溶栓治疗。其中有效２１例，无效１３例。有效组在溶栓后２小时、８小时、２４小时的ＱＴｃ离散度（ＱＴｃｄ）与溶栓前相比较，有下降趋势，但未达到统计显著性。无效组在溶栓后２小时、８小时、２４小时的ＱＴｃｄ与溶栓前相比较，有显著性延长（Ｐ＜０００１）。有效组与无效组相比，溶栓后２小时、８小时、２４小时之ＱＴｃｄ，差异有显著性（Ｐ＜０００１）。

The changes of QTcd after thrombolitic treatment by recombinant tissue-type plasminogen activator were studied in 36 patients with acute myocardial infarction.It was found that QTcd was shortted without significance in 21 patients with successful thrombolitic treatment at 2,8 and 24 hours later,but those with unsuccessful result prolonged significantly (n=13,P<0 001). The differences of QTcd between successful and unsuccessful patients at 2,8 and 24 hours later were significant (P<0 001).