高危人群粉尘、砷暴露与肺癌发病关系的队列研究

Cohort Study on the Relationship between the Exposure to Dust & Arsenic and the Lung Cancer in High rick Population

为探讨粉尘、砷等职业危害的致肺癌作用及各因素间的作用方式，选取１９９２～１９９４年云南锡矿高危人群，采用前瞻性队列方法进行了研究，并应用Ｐｏｉｓｓｏｎ回归模型分析了研究数据。结果显示，粉尘、砷暴露与肺癌发生有关，可能是云锡矿工和冶炼工肺癌的致病因素，但云锡粉尘中尚含有砷、锡、铅、铜、铁、铬、镍、镉、铍等多种致癌物和可疑致癌物，其在肺癌发病中的作用还需进一步探讨。

To explore the relationship between the exposure to dust,arsenic and the lung cancer,and the interactions of these factors in carcinogensis,a 3 year cohort study was conducted in Yunnan Tin Corporation from 1992 to 1994, the workers were high risk population of lung cancer,the detailed environmental data were collected and Poisson regression models were applied for data analysis.The results showed that the exposure to dust and arsenic was related to the genesis of lung cancer among miners and smelters.Owing to the complex components of mine dust such as nickel,beryllium,chromium,cadmium lead ect,was there any joint carcinogenic effect existed,seemed still to need further inquiry.