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右旋肌醇甲醚腺嘌呤核苷类似物的合成 被引量：1

Synthesis of 3-O-Methyl-D-chiro-inositol Adenosine Analogues
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摘要 以右旋肌醇甲醚为原料,经保护的甲烷磺酸酯与腺嘌呤缩合,合成了腺嘌呤核苷类似物5。此外,化合物3经酸水解,再经环氧化高产率地合成了重要的中间体7,腺嘌呤在强有机碱存在下,对环氧化合物7进行区域性的开环反应,合成了另外两种腺嘌呤核苷类似物8和9。 Using 3-O-methyl-D-chiro-inositol as starting material, the title compound 5 was synthesized by condensation between adenine and methanesulfonate 3. Additionally, compounds 8 and 9 were prepared through the opening of epoxide ring in 7 by adenine. The key intermediate 7 was obtained in good yield via an epoxidation from mono-mesylate 6. The process of opening of epoxide ring appeared to be regioselective in presence of 1,8-diazabicyclo [ 5.4.0 ] undec-7-ene （DBU）.
作者 詹天荣 杨慧娟
机构地区 青岛科技大学化学与分子工程学院 青岛大学师范学院
出处 《化学通报》 CAS CSCD 北大核心 2008年第2期150-153,共4页 Chemistry
基金 青岛科技大学博士科研启动基金项目(0022257)资助
关键词 右旋肌醇甲醚 碳环核苷类似物 腺嘌呤 区域选择性 3- O-Methyl-D- chiro-inositol, Carbocyclic nucleoside analogues, Adenine, Regioselectivity
分类号 TQ463 [化学工程—制药化工]
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参考文献9

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同被引文献9

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化学通报
2008年 第2期

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