丹参注射液对实验性动脉内膜增生的抑制作用

The inhibitory effect of salvia miltiorrhiza injection on proliferation of arterial intima

目的：探讨丹参注射液用于预防经皮腔内冠状动脉成形术（ＰＴＣＡ）后再狭窄的可能性。方法：利用Ｆｉｓｈｍａｎ空气干燥法建立了大鼠的动脉损伤模型，观察丹参注射液对动脉损伤后内膜增生的影响。结果：丹参治疗组的动脉最大内膜厚度〔（１８．７３±１．８２）μｍ〕与对照组动脉最大内膜厚度〔（８０．１７±２３．４９）μｍ〕比较明显减薄，具有极显著性差异（Ｐ＜０．０１）。结论：丹参注射液可能具有预防ＰＴＣＡ后动脉再狭窄的作用。

Objective:To study the possibility of salvia miltiorrhiza injection in the prevention of restenosis after percutaneous transluminal coronary angioplasty (PTCA).Methods:We established a rat carotid arterial injury model using Fishman airdry method,and observed the effect of salvia miltiorrhiza injection on the proliferation on intima after arterial injury.Results:It showed that the intimal thickness in the salvia miltiorrhiza injectiontreated group was much thinner than that in the control group (18 73±1 82)vs.(80 17±23 49)μm, P <0 01 .Conclusions:It is indicated that salvia miltiorrhiza may have beneficial effect in the prevention of restenosis after PTCA.