一种新型端氨基环磷腈衍生物的合成

Synthesis of a novel amine-terminated cyclotriphosphazene derivative

以六氯环三磷腈为前体制备了六甘氨酸乙酯取代环三磷腈,然后采用氨基-酯交换法以双氨基化合物乙二胺直接与六甘氨酸乙酯取代环三磷腈反应合成了端氨基环磷腈衍生物。化合物六甘氨酸乙酯取代环三磷腈和端氨基环磷腈衍生物的结构经IR、1H-NMR和质谱表征。讨论了反应温度、反应时间和投料比对端氨基环磷腈衍生物合成反应的影响,以及六甘氨酸乙酯取代环三磷腈和端氨基环磷腈衍生物后处理过程。该合成方法的反应条件温和,操作简单且收率高达95%。

A glycine ethyl ester of cyclotriphosphazene has been synthesized from hexachlorocyclotriphosphazene as precursor. Subsequent reaction of the glycine ethyl ester cyclotriphosphazene with ethylenediamine in an ＂amino-ester exchange reaction＂ afforded an amine terminated cyclotriphosphazene derivative. This method has the advantages of convenient manipulation, mild reaction conditions and high yield （95 % ）. All synthesized compounds were characterized by IR,^1H-NMR and mass spectroscopies. The influence of varying the synthesis conditions, such as reaction temperature, reaction time and ratio of reactants was investigated.