靶向给药在肿瘤治疗中的应用进展

Advances of Targeted Therapy in Tumor Therapy

目的:介绍近年来分子靶向药物治疗肿瘤的临床研究和应用。方法:收集国内外近期相关文献对靶向药物治疗肿瘤的现状及关键技术进行评价。结果及结论:分子靶向药物是利用肿瘤细胞与正常细胞之间分子细胞生物学上的差异,采用封闭受体、抑制血管生成、阻断信号传导通路等方法作用于肿瘤细胞特定的靶点,特异性地抑制肿瘤细胞生长,促使肿瘤细胞凋亡。分子靶向治疗比传统的化疗特异性强、毒副反应小,将成为今后肿瘤治疗的新趋势。现代生物技术发展迅猛,针对肿瘤细胞的靶向性治疗面临着前所未有的机遇和挑战,具有新的概念和内涵。现有方法或多或少都存在缺陷。充分利用多学科综合性发展的进步将加速新型靶向载体系统的出现。

OBJECTIVE： To introduce recent advances in clinical research on the application of molecular targeted drugs in tumor therapy. METHODS： The pertinent literatures both home and abroad were reviewed to evaluate the status quo and key technologies of applying molecular targeted drugs in tumor therapy. RESULTS ＆ CONCLUSION： The targeted therapy depends on the difference between the cancer cells and normal cells and aims specifically to inhibit the tumor growth and metastasis and to modulate the apoptosis of tumor cells by blocking receptors, inhibiting angiogenesis and blocking conductive passages of signal etc. Targeted therapy is expected to be a new trend in tumor therapy for its stronger specificity and lower toxicity as compared with traditional chemotherapy. With the rapid development of modern biotechnology, the targeted therapy aiming specifically to inhibit the tumor growth was faced with unprecedented opportunities and challenges and which has extended meaning and connotation. More or less, the modern technology has its own drawbacks. Taking advantage of the progress in the comprehensive development of multi - subjects can facilitate the appearance of new type targeting vector system.